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Proceedings Paper

Health monitoring of biomaterials from molecular fingerprints
Author(s): Reiner Salzer; Gerald Steiner; Christoph Krafft; Cordelia A. Zimmerer; Sibel Tunc
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Paper Abstract

Structural changes in proteins may result in interactions between proteins themselves or between proteins and other biomolecules, which in turn may introduce deterioration of the health state of the system, might it be biological or biomimetic. The initial structural changes in proteins can not be observed by established methods of material analysis like X-ray diffraction or NMR spectroscopy, because proteins in biological cells have an extremely low abundance and are in the non-crystalline state. An obvious gap exists between sequencing techniques for amino acids and the molecular understanding of the functional properties of a particular protein. Vibrational spectroscopic methods offer the potential of fast and accurate characterization of essential supramolecular properties in the native state of the biomaterial. Imaging techniques recently became available for both FTIR and Raman spectroscopy. Here we report on the utilization of the enormous information content of FTIR and Raman spectra for health monitoring in engineering and medicine.

Paper Details

Date Published: 21 July 2004
PDF: 8 pages
Proc. SPIE 5394, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems III, (21 July 2004); doi: 10.1117/12.538374
Show Author Affiliations
Reiner Salzer, Technische Univ. Dresden (Germany)
Gerald Steiner, Technische Univ. Dresden (Germany)
Christoph Krafft, Technische Univ. Dresden (Germany)
Cordelia A. Zimmerer, Technische Univ. Dresden (Germany)
Sibel Tunc, Akdeniz Univ. (Turkey)

Published in SPIE Proceedings Vol. 5394:
Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems III
Tribikram Kundu, Editor(s)

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