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Proceedings Paper

Analysis of cerebrospinal fluid for detection of ruptured cerebral aneurysm using spectrophotometry and signal processing techniques
Author(s): Anindya Majumder; James Caffery; Prashant R. Bhadri; Fred Richard Beyette; Joseph F. Clark; Chad J. Morgan; Gail J. Pyne; Mario Zuccarello; Ed Jauch; Ken R. Wagner
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Paper Abstract

An accurate quantification of bilirubin in cerebrospinal fluid (CSF) will provide a simple, sensitive and rapid mechanism for detecting subarachnoid hemorrhage (SAH) and for its differentiation from a traumatic spinal tap. Derivative analysis of the spectrophotometric data provides a model for determining bilirubin in CSF where the primary contaminant is Methemoglobin. Bilirubin values are determined in the range 0-9mg/dl within a methemoglobin concentration of 4.6g/dl using the derivative analysis method. The algorithm is also implemented on test samples in which the bilirubin value is constant (4.6mg/dl) and the methemoglobin varies between 0-9g/dl. The performance of the derivative analysis method is compared to the modified minimum distance method developed in reference one. We suggest a combination of these methods for accurate bilirubin estimation in CSF/hemoglobin. This will provide the foundation for the development of a portable user friendly device for diagnosis of SAH.

Paper Details

Date Published: 13 July 2004
PDF: 9 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.538200
Show Author Affiliations
Anindya Majumder, Univ. of Cincinnati (United States)
James Caffery, Univ. of Cincinnati (United States)
Prashant R. Bhadri, Univ. of Cincinnati (United States)
Fred Richard Beyette, Univ. of Cincinnati (United States)
Joseph F. Clark, Univ. of Cincinnati College of Medicine (United States)
Chad J. Morgan, Univ. of Cincinnati College of Medicine (United States)
Gail J. Pyne, Univ. of Cincinnati College of Medicine (United States)
Mario Zuccarello, Univ. of Cincinnati College of Medicine (United States)
Ed Jauch, Univ. of Cincinnati College of Medicine (United States)
Ken R. Wagner, Univ. of Cincinnati College of Medicine (United States)


Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong; Nikiforos Kollias; Kenton W. Gregory; Henry Hirschberg; Reza S. Malek; Abraham Katzir; David S. Robinson; Kenneth Eugene Bartels; Eugene A. Trowers; Werner T.W. de Riese; Lawrence S. Bass; Lloyd P. Tate; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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