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Proceedings Paper

Functional imaging of the vascular bed by dynamic optical tomography
Author(s): Randall Locke Barbour; Harry L. Graber; Yaling Pei; Christoph H. Schmitz; Yong Xu; Adriana Di Martino; F. Xavier Castellanos; David P. Klemer; Rosemarie E. Hardin; Nelson A. Franco; Michael S. Katz; M. E. Zenilman; Alessandro G. Smeraldi; Thomas F. Panetta
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Paper Abstract

In this report we present a brief outline of our technological approaches to developing a comprehensive imaging platform suitable for the investigation of the dynamics of the hemoglobin signal in large tissue structures using NIRS imaging techniques. Our approach includes a combined hardware and software development effort that provides for i) hardware integration, ii) system calibration, iii) data integrity checks, iv) image recovery, v) image enhancement and vi) signal processing. Presented are representative results obtained from human subjects that explore the sensitivity and other capabilities of the measuring system to detect focal hemodynamic responses in the head, breast and limb of volunteers. Results obtained support the contention that time-series NIRS imaging is a powerful and sensitive technique for exploring the hemodynamics of healthy and diseased tissues.

Paper Details

Date Published: 30 April 2004
PDF: 18 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.537957
Show Author Affiliations
Randall Locke Barbour, SUNY Downstate Medical Ctr. (United States)
Harry L. Graber, SUNY Downstate Medical Ctr. (United States)
Yaling Pei, NIRx Medical Technologies LLC (United States)
Christoph H. Schmitz, SUNY Downstate Medical Ctr. (United States)
Yong Xu, SUNY Downstate Medical Ctr. (United States)
Adriana Di Martino, New York Univ. (United States)
F. Xavier Castellanos, New York Univ. (United States)
David P. Klemer, SUNY Downstate Medical Ctr. (United States)
Rosemarie E. Hardin, SUNY Downstate Medical Ctr. (United States)
Nelson A. Franco, SUNY Downstate Medical Ctr. (United States)
Michael S. Katz, SUNY Downstate Medical Ctr. (United States)
M. E. Zenilman, SUNY Downstate Medical Ctr. (United States)
Alessandro G. Smeraldi, Staten Island Univ. Hospital (United States)
Thomas F. Panetta, Staten Island Univ. Hospital (United States)


Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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