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Proceedings Paper

Photonic and magnetic nanoexplorers for biomedical use: from subcellular imaging to cancer diagnostics and therapy
Author(s): Brian Ross; Alnawaz Rehemtulla; Yong-Eun Lee Koo; Ramachandra Reddy; Gwangseong Kim; Caleb Behrend; Sarah Buck; Randal J. Schneider; Martin A. Philbert; Ralph Weissleder; Raoul Kopelman
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Paper Abstract

A paradigm for brain cancer detection, treatment, and monitoring uses synergistic, multifunctional, biomedical nanoparticles for: (1) external delivery to cancer cells of singlet oxygen and reactive oxygen species (ROS), but no drugs, thus avoiding multi-drug resistance, (2) photodynamic generation of singlet oxygen and ROS by a conserved critical mass of photosensitizer, (3) enhancement of magnetic relaxivity providing for MRI contrast, (4) control of plasma residence time, (5) specific cell targeting, (6) minimized toxicity, (7) measurement of tumor kill with diffusion MRI. The 40 nm polyacrylamide nanoparticles contained Photofrin, iron-oxide (or Gd), polyethylene glycol and targeting moieties. In-vivo tumor growth was halted and even reversed.

Paper Details

Date Published: 1 June 2004
PDF: 8 pages
Proc. SPIE 5331, Nanobiophotonics and Biomedical Applications, (1 June 2004); doi: 10.1117/12.537653
Show Author Affiliations
Brian Ross, Univ. of Michigan (United States)
Alnawaz Rehemtulla, Univ. of Michigan (United States)
Yong-Eun Lee Koo, Univ. of Michigan (United States)
Ramachandra Reddy, Molecular Therapeutics, Inc. (United States)
Gwangseong Kim, Univ. of Michigan (United States)
Caleb Behrend, Univ. of Michigan (United States)
Sarah Buck, Univ. of Michigan (United States)
Randal J. Schneider, Univ. of Michigan (United States)
Martin A. Philbert, Univ. of Michigan (United States)
Ralph Weissleder, Massachusetts General Hospital (United States)
Raoul Kopelman, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 5331:
Nanobiophotonics and Biomedical Applications
Alexander N. Cartwright, Editor(s)

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