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Proceedings Paper

Automated 4D lung computed tomography reconstruction during free breathing for conformal radiation therapy
Author(s): Issam M. El Naqa; Daniel A. Low; Gary E. Christensen; Parag J. Parikh; Joo Hyun Song; Michelle M. Nystrom; Wei Lu; Joseph O. Deasy; James P. Hubenschmidt; Sasha H. Wahab; Sasa Mutic; Anurag K. Singh; Jeffrey D. Bradley
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Paper Abstract

We are developing 4D-CT to provide breathing motion information (trajectories) for radiation therapy treatment planning of lung cancer. Potential applications include optimization of intensity-modulated beams in the presence of breathing motion and intra-fraction target volume margin determination for conformal therapy. The images are acquired using a multi-slice CT scanner while the patient undergoes simultaneous quantitative spirometry. At each couch position, the CT scanner is operated in ciné mode and acquires up to 15 scans of 12 slices each. Each CT scan is associated with the measured tidal volume for retrospective reconstruction of 3D CT scans at arbitrary tidal volumes. The specific tasks of this project involves the development of automated registration of internal organ motion (trajectories) during breathing. A modified least-squares based optical flow algorithm tracks specific features of interest by modifying the eigenvalues of gradient matrix (gradient structural tensor). Good correlations between the measured motion and spirometry-based tidal volume are observed and evidence of internal hysteresis is also detected.

Paper Details

Date Published: 30 April 2004
PDF: 7 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.536141
Show Author Affiliations
Issam M. El Naqa, Washington Univ. School of Medicine (United States)
Daniel A. Low, Washington Univ. School of Medicine (United States)
Gary E. Christensen, Univ. of Iowa (United States)
Parag J. Parikh, Washington Univ. School of Medicine (United States)
Joo Hyun Song, Univ. of Iowa (United States)
Michelle M. Nystrom, Washington Univ. School of Medicine (United States)
Wei Lu, Washington Univ. School of Medicine (United States)
Joseph O. Deasy, Washington Univ. School of Medicine (United States)
James P. Hubenschmidt, Washington Univ. School of Medicine (United States)
Sasha H. Wahab, Washington Univ. School of Medicine (United States)
Sasa Mutic, Washington Univ. School of Medicine (United States)
Anurag K. Singh, Washington Univ. School of Medicine (United States)
Jeffrey D. Bradley, Washington Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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