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Proceedings Paper

Three-dimensional visualization of morphology and ventilation procedure (air flow and diffusion) of a subdivision of the acinus using synchrotron radiation microtomography of the human lung specimens
Author(s): Kenji Shimizu; Hirohiko Ikura; Junpei Ikezoe; Tomofumi Nagareda; Naoto Yagi; Keiji Umetani; Yutaka Imai
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Paper Abstract

We have previously reported a synchrotron radiation (SR) microtomography system constructed at the bending magnet beamline at the SPring-8. This system has been applied to the lungs obtained at autopsy and inflated and fixed by Heitzman’s method. Normal lung and lung specimens with two different types of pathologic processes (fibrosis and emphysema) were included. Serial SR microtomographic images were stacked to yield the isotropic volumetric data with high-resolution (12 μm3 in voxel size). Within the air spaces of a subdivision of the acinus, each voxel is segmented three-dimensionally using a region growing algorithm (“rolling ball algorithm”). For each voxel within the segmented air spaces, two types of voxel coding have been performed: single-seeded (SS) coding and boundary-seeded (BS) coding, in which the minimum distance from an initial point as the only seed point and all object boundary voxels as a seed set were calculated and assigned as the code values to each voxel, respectively. With these two codes, combinations of surface rendering and volume rendering techniques were applied to visualize three-dimensional morphology of a subdivision of the acinus. Furthermore, sequentially filling process of air into a subdivision of the acinus was simulated under several conditions to visualize the ventilation procedure (air flow and diffusion). A subdivision of the acinus was reconstructed three-dimensionally, demonstrating the normal architecture of the human lung. Significant differences in appearance of ventilation procedure were observed between normal and two pathologic processes due to the alteration of the lung architecture. Three-dimensional reconstruction of the microstructure of a subdivision of the acinus and visualization of the ventilation procedure (air flow and diffusion) with SR microtomography would offer a new approach to study the morphology, physiology, and pathophysiology of the human respiratory system.

Paper Details

Date Published: 30 April 2004
PDF: 8 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.536034
Show Author Affiliations
Kenji Shimizu, Tokai Univ. School of Medicine (Japan)
Hirohiko Ikura, Ehime Univ. (Japan)
Junpei Ikezoe, Ehime Univ. (Japan)
Tomofumi Nagareda, Takarazuka Municipal Hospital (Japan)
Naoto Yagi, Japan Synchrotron Radiation Research Institute (Japan)
Keiji Umetani, Japan Synchrotron Radiation Research Institute (Japan)
Yutaka Imai, Tokai Univ. School of Medicine (Japan)


Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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