Share Email Print
cover

Proceedings Paper

Anatomo-clinical overlapping maps (AnaCOM): a new method to create anatomo-functional maps from neuropsychological tests and structural MRI scan of subjects with brain lesions
Author(s): Serge R. J. Kinkingnehun; Foucaud du Boisgueheneuc; Jean-Louis Golmard; Sandy X. Zhang; Richard Levy; Bruno Dubois
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

We have developed a new technique to analyze correlations between brain anatomy and its neurological functions. The technique is based on the anatomic MRI of patients with brain lesions who are administered neuropsychological tests. Brain lesions of the MRI scans are first manually segmented. The MRI volumes are then normalized to a reference map, using the segmented area as a mask. After normalization, the brain lesions of the MRI are segmented again in order to redefine the border of the lesions in the context of the normalized brain. Once the MRI is segmented, the patient's score on the neuropsychological test is assigned to each voxel in the lesioned area, while the rest of the voxels of the image are set to 0. Subsequently, the individual patient's MRI images are superimposed, and each voxel is reassigned the average score of the patients who have a lesion at that voxel. A threshold is applied to remove regions having less than three overlaps. This process leads to an anatomo-functional map that links brain areas to functional loss. Other maps can be created to aid in analyzing the functional maps, such as one that indicates the 95% confidence interval of the averaged scores for each area. This anatomo-clinical overlapping map (AnaCOM) method was used to obtain functional maps from patients with lesions in the superior frontal gyrus. By finding particular subregions more responsible for a particular deficit, this method can generate new hypotheses to be tested by conventional group methods.

Paper Details

Date Published: 30 April 2004
PDF: 10 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.535839
Show Author Affiliations
Serge R. J. Kinkingnehun, Institut National de la Sante et de la Recherche Medicale (France)
Institut Federatif de Recherche (France)
Fondation Nationale de Gerontologie (France)
Foucaud du Boisgueheneuc, Institut National de la Sante et de la Recherche Medicale (France)
Jean-Louis Golmard, Groupe Hospitalier Pitie-Salpetriere (France)
Sandy X. Zhang, Institut National de la Sante et de la Recherche Medicale (France)
Massachusetts Institute of Technology (United States)
Richard Levy, Institut National de la Sante et de la Recherche Medicale (France)
Bruno Dubois, Institut National de la Sante et de la Recherche Medicale (France)
Institut Federatif de Recherche (France)


Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

© SPIE. Terms of Use
Back to Top