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Proceedings Paper

MR diffusion tensor imaging (DTI) and neuropsychological testing for neuronal connectivity in Alzheimer's disease (AD) patients
Author(s): Jianhui Zhong; Hongyan Ni; Tong Zhu; Sven Ekholm; Voyko Kavcic
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Paper Abstract

We have used MR DTI to identify relevant brain structures involved in visuospatial processing, in an attempt to link perceptual and attentional impairments to WM changes in Alzheimer's disease (AD) patients. Correlation of DTI measured parameters with results of several neuropsychological tests will be reported here. Several issues related to quantitation of DTI parameters in ROI analysis are addressed. In spite of only a small number of subjects were studied so far, we found not only that AD patients showed significant decrease of white matter (WM) integrity in corpus callosum (CC), most prominent at the posterior portion, but also found significant correlations between the DTI parameters and scores from several neuropsychological tests. Our preliminary results suggest that DTI help to improve the overall accuracy rate in distinguishing between early AD onset and age-related functional decline, and potentially may improve efficiency in differentiating between different types of dementia.

Paper Details

Date Published: 30 April 2004
PDF: 12 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.535752
Show Author Affiliations
Jianhui Zhong, Univ. of Rochester (United States)
Hongyan Ni, Univ. of Rochester (United States)
Tong Zhu, Univ. of Rochester (United States)
Sven Ekholm, Univ. of Rochester (United States)
Voyko Kavcic, Univ. of Rochester (United States)

Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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