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Proceedings Paper

Changes in pulmonary arterial wall mechanical properties and lumenal architecture with induced vascular remodeling
Author(s): Robert C. Molthen; Amy E. Heinrich; Steven T. Haworth; Christopher A. Dawson
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Paper Abstract

To explore and quantify pulmonary arterial remodeling we used various methods including micro-CT, high-resolution 3-dimensional x-ray imaging, to examine the structure and function of intact pulmonary vessels in isolated rat lungs. The rat is commonly used as an animal model for studies of pulmonary hypertension (PH) and the accompanying vascular remodeling, where vascular remodeling has been defined primarily by changes in the vessel wall composition in response to hypertension inducing stimuli such as chronic hypoxic exposure (CHE) or monocrotaline (MCT) injection. Little information has been provided as to how such changes affect the vessel wall mechanical properties or the lumenal architecture of the pulmonary arterial system that actually account for the hemodynamic consequences of the remodeling. In addition, although the link between primary forms of pulmonary hypertension and inherited genetics is well established, the role that genetic coding plays in hemodynamics and vascular remodeling is not. Therefore, we are utilizing Fawn-Hooded (FH), Sprague-Dawley (SD) and Brown Norway (BN)rat strains along with unique imaging methods to parameterize both vessel distensibility and lumenal morphometry using a principal pulmonary arterial pathway analysis based on self-consistency. We have found for the hypoxia model, in addition to decreased body weight, increased hematocrit, increased right ventricular hypertrophy, the distensibility of the pulmonary arteries is shown to decrease significantly in the presence of remodeling.

Paper Details

Date Published: 30 April 2004
PDF: 11 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.535738
Show Author Affiliations
Robert C. Molthen, Medical College of Wisconsin (United States)
Marquette Univ. (United States)
Zablocki Veterans Affairs Medical Ctr. (United States)
Amy E. Heinrich, Medical College of Wisconsin (United States)
Steven T. Haworth, Medical College of Wisconsin (United States)
Christopher A. Dawson, Medical College of Wisconsin (United States)
Marquette Univ. (United States)
Zablocki Veterans Affairs Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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