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Proceedings Paper

Neutron stimulated emission computed tomography of stable isotopes
Author(s): Carey E. Floyd Jr.; Calvin Howell; Brian P. Harrawood; Alexander Crowell; Anuj Kapadia; Robert Macri; Jessie Xia; Ronald Pedroni; James E. Bowsher; Mathew Kiser; Georgia D. Tourassi; Werner Tornow; Richard Walter
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Paper Abstract

Here we report on the development of a new molecular imaging technique using inelastic scattering of fast neutrons. Earlier studies demonstrated a significant difference in trace element concentrations between benign and malignant tissue for several cancers including breast, lung, and colon. Unfortunately, the measurement techniques were not compatible with living organisms and this discovery did not translate into diagnostic techniques. Recently we have developed a tomographic approach to measuring the trace element concentrations using neutrons to stimulate characteristic gamma emission from atomic nuclei in the body. Spatial projections of the emitted energy spectra allow tomographic image reconstruction of the elemental concentrations. In preliminary experiments, spectra have been acquired using a 7.5MeV neutron beam incident on several multi-element phantoms. These experiments demonstrate our ability to determine the presence of Oxygen, Carbon, Copper, Iron, and Calcium. We describe the experimental technique and present acquired spectra.

Paper Details

Date Published: 6 May 2004
PDF: 7 pages
Proc. SPIE 5368, Medical Imaging 2004: Physics of Medical Imaging, (6 May 2004); doi: 10.1117/12.535350
Show Author Affiliations
Carey E. Floyd Jr., Duke Univ. Medical Ctr. (United States)
Duke Univ. (United States)
Calvin Howell, Duke Univ. (United States)
Brian P. Harrawood, Duke Univ. Medical Ctr. (United States)
Alexander Crowell, Duke Univ. (United States)
Anuj Kapadia, Duke Univ. (United States)
Robert Macri, Duke Univ. (United States)
Jessie Xia, Duke Univ. (United States)
Ronald Pedroni, Univ. of North Carolina/Greensboro (United States)
James E. Bowsher, Duke Univ. Medical Ctr. (United States)
Mathew Kiser, Duke Univ. (United States)
Georgia D. Tourassi, Duke Univ. Medical Ctr. (United States)
Werner Tornow, Duke Univ. (United States)
Richard Walter, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 5368:
Medical Imaging 2004: Physics of Medical Imaging
Martin J. Yaffe; Michael J. Flynn, Editor(s)

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