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Proceedings Paper

Methodology for quantifying and visualizing cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging
Author(s): Hans Jorgen Gundersen; Soren Baarsgaard Hansen; Albert Gjedde; Hans Stodkilde-Jorgensen; Jorgen Marqversen; Ralf Agger; Tom E. Andersen; Charlotte C. Fleischer; Mikkel Steen Petersen; Marianne E. Hokland; Egil F. Hulgaard; Jan Trost Jorgensen; Ulrik Skands
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Paper Abstract

A method for precise and sensitive organ specific quantification of 124I (124IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.

Paper Details

Date Published: 30 April 2004
PDF: 10 pages
Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); doi: 10.1117/12.535206
Show Author Affiliations
Hans Jorgen Gundersen, Aarhus Univ. (Denmark)
Soren Baarsgaard Hansen, Aarhus Univ. Hospital (Denmark)
Albert Gjedde, Aarhus Univ. Hospital (Denmark)
Hans Stodkilde-Jorgensen, Aarhus Univ. Hospital (Denmark)
Jorgen Marqversen, Aarhus Univ. Hospital (Denmark)
Ralf Agger, Aarhus Univ. (Denmark)
Tom E. Andersen, Aarhus Univ. (Denmark)
Charlotte C. Fleischer, Aarhus Univ. (Denmark)
Mikkel Steen Petersen, Aarhus Univ. (Denmark)
Marianne E. Hokland, Aarhus Univ. (Denmark)
Egil F. Hulgaard, T-cellic A/S (Denmark)
Jan Trost Jorgensen, T-cellic A/S (Denmark)
Ulrik Skands, T-cellic A/S (Denmark)

Published in SPIE Proceedings Vol. 5369:
Medical Imaging 2004: Physiology, Function, and Structure from Medical Images
Amir A. Amini; Armando Manduca, Editor(s)

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