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Proceedings Paper

Soft-tissue contrast resolution within the head of human cadaver by means of flat-detector-based cone-beam CT
Author(s): Jens Wiegert; Matthias Bertram; Dirk Schaefer; Norbert Conrads; Niels Noordhoek; Kees de Jong; Til Aach; Georg Rose
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Paper Abstract

In this paper, soft tissue contrast visibility in neural applications is investigated for volume imaging based on flat X-ray detector cone-beam CT. Experiments have been performed on a high precision bench-top system with rotating object table and fixed X-ray tube-detector arrangement. Several scans of a post mortem human head specimen have been performed under various conditions. Hereby two different flat X-ray detectors with 366 x 298mm2 (Trixell Pixium 4700) and 176 x 176mm2 (Trixell Pixium 4800) active area have been employed. During a single rotation up to 720 projections have been acquired. For reconstruction of the 3D images a Feldkamp algorithm has been employed. Reconstructed images of the head of human cadaver demonstrate that added soft tissue contrast down to 10 HU is detectable for X-ray dose comparable to CT. However, the limited size of the smaller detector led to truncation artifacts, which were partly compensated by extrapolation of the projections outside the field of view. To reduce cupping artifacts resulting from scattered radiation and to improve visibility of low contrast details, a novel homogenization procedure based on segmentation and polynomial fitting has been developed and applied on the reconstructed voxel data. Even for narrow HU-Windows, limitations due to scatter induced cupping artifacts are no longer noticeable after applying the homogenization procedure.

Paper Details

Date Published: 6 May 2004
PDF: 8 pages
Proc. SPIE 5368, Medical Imaging 2004: Physics of Medical Imaging, (6 May 2004); doi: 10.1117/12.535191
Show Author Affiliations
Jens Wiegert, Univ. of Luebeck (Germany)
Philips Research Labs. (Germany)
Matthias Bertram, Philips Research Labs. (Germany)
Dirk Schaefer, Philips Research Labs. (Germany)
Norbert Conrads, Philips Research Labs. (Germany)
Niels Noordhoek, Philips Medical Systems (Netherlands)
Kees de Jong, Univ. van Amsterdam (Netherlands)
Til Aach, Univ. of Luebeck (Germany)
Georg Rose, Philips Research Labs. (Germany)

Published in SPIE Proceedings Vol. 5368:
Medical Imaging 2004: Physics of Medical Imaging
Martin J. Yaffe; Michael J. Flynn, Editor(s)

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