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Proceedings Paper

Novel multifunctional near-infrared fluorescent nanoparticles: integrating nanotechnology and biophotonics
Author(s): Vishal Saxena; Mostafa Sadoqi; S. Kumar; Jun Shao
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Paper Abstract

The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

Paper Details

Date Published: 1 June 2004
PDF: 7 pages
Proc. SPIE 5331, Nanobiophotonics and Biomedical Applications, (1 June 2004); doi: 10.1117/12.534329
Show Author Affiliations
Vishal Saxena, St. John's Univ. (United States)
Mostafa Sadoqi, St. John's Univ. (United States)
S. Kumar, Polytechnic Univ. (United States)
Jun Shao, St. John's Univ. (United States)

Published in SPIE Proceedings Vol. 5331:
Nanobiophotonics and Biomedical Applications
Alexander N. Cartwright, Editor(s)

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