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Proceedings Paper

Novel near-infrared nanoparticlulate biomarker: preparation and stability studies
Author(s): Vishal Saxena; Mostafa Sadoqi; Sunil Kumar; Jun Shao
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Paper Abstract

Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

Paper Details

Date Published: 14 June 2004
PDF: 7 pages
Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); doi: 10.1117/12.534317
Show Author Affiliations
Vishal Saxena, St. John's Univ. (United States)
Mostafa Sadoqi, St. John's Univ. (United States)
Sunil Kumar, Polytechnic Univ. (United States)
Jun Shao, St. John's Univ. (United States)

Published in SPIE Proceedings Vol. 5329:
Genetically Engineered and Optical Probes for Biomedical Applications II
Alexander P. Savitsky; Darryl J. Bornhop; Ramesh Raghavachari; Samuel I. Achilefu, Editor(s)

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