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Proceedings Paper

Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states
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Paper Abstract

Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscattering as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

Paper Details

Date Published: 1 July 2004
PDF: 4 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.533356
Show Author Affiliations
Alexander I. Kholodnykh, Univ. of Texas Medical Branch/Galveston (United States)
Kamran Hosseini, Univ. of Texas Medical Branch/Galveston (United States)
Kirill V. Larin, Univ. of Texas Medical Branch/Galveston (United States)
Alexandra A. Vassilieva, Univ. of Texas Medical Branch/Galveston (United States)
Rinat O. Esenaliev, Univ. of Texas Medical Branch/Galveston (United States)
Massoud Motamedi, Univ. of Texas Medical Branch/Galveston (United States)


Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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