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Proceedings Paper

NIR optical probes targeting glucose transporters
Author(s): Hui Li; Juan Chen; Min Zhang; Zhihong Zhang; David Benaron; Britton Chance; Jerry D. Glickson; Gang Zheng
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Paper Abstract

A current limitation of NIR imaging is the lack of sufficient tumor-to-tissue contrast due to the nonspecific nature of delivering the dye to the tumor. Utilizing one of the most important cancer signatures, the overexpression of GLUTs, we have developed a series of 2-deoxyglucose conjugated NIR dyes (NIR- 2DG) to enhance tumor selectivity. This uptake mechanism is first confirmed in vitro by confocal microscopy and flow cytometry studies with various cancer cells. Following intravenously administration to animals, NIR-2DGs are selectively accumulated in the tumor compared to the surrounding normal tissue as observed by ex vivo and in vivo fluorescence imaging techniques.

Paper Details

Date Published: 14 June 2004
PDF: 8 pages
Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); doi: 10.1117/12.533148
Show Author Affiliations
Hui Li, Univ. of Pennsylvania (United States)
Juan Chen, Univ. of Pennsylvania (United States)
Min Zhang, Univ. of Pennsylvania (United States)
Shanghai Univ. (China)
Zhihong Zhang, Univ. of Pennsylvania (United States)
Huazhong Univ. of Science and Technology (China)
David Benaron, Spectros Corp. (United States)
Britton Chance, Univ. of Pennsylvania (United States)
Jerry D. Glickson, Univ. of Pennsylvania (United States)
Gang Zheng, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 5329:
Genetically Engineered and Optical Probes for Biomedical Applications II
Alexander P. Savitsky; Darryl J. Bornhop; Ramesh Raghavachari; Samuel I. Achilefu, Editor(s)

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