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Proceedings Paper

Measurement of backscattered light from the cold-injured brain: feasibility study of noninvasive monitoring of brain edema
Author(s): Yoshinori Ueda; Shunichi Sato; Daizoh Saitoh; Hiroshi Nawashiro; Hidetoshi Ooigawa; Katsuji Shima; Yoshiaki Okada; Hiroshi Ashida; Minoru Obara
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Paper Abstract

Brain edema causes an increase in brain tissue volume which results from an accumulation of transudate due to the increased permeability of the brain capillaries. Assuming the transudate to be the material with a low scattering coefficient, brain edema would decrease scattering coefficient of the brain tissue, and diffuse reflectance from the brain may, therefore, be decreased. We examined whether brain edema can be detected or not by measuring the diffuse light reflected from the brain. We induced brain edema by cold injury in rats. The rat skull was irradiated with 633-nm HeNe laser through an optical fiber, and the diffuse light reflected from the brain was collected through another optical fiber. Intensity of the diffuse light reflectance was measured with a polychromator as functions of the time and position on the skull. We found that intensity of the detected diffuse light reflectance decreased at 24 h after injury in the surround area of the injury, suggesting that brain edema can be detected by measuring the diffuse light reflected from the brain.

Paper Details

Date Published: 13 July 2004
PDF: 4 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.533024
Show Author Affiliations
Yoshinori Ueda, Keio Univ. (Japan)
Shunichi Sato, National Defense Medical College (Japan)
Daizoh Saitoh, National Defense Medical College (Japan)
Hiroshi Nawashiro, National Defense Medical College (Japan)
Hidetoshi Ooigawa, National Defense Medical College (Japan)
Katsuji Shima, National Defense Medical College (Japan)
Yoshiaki Okada, National Defense Medical College (Japan)
Hiroshi Ashida, National Defense Medical College (Japan)
Minoru Obara, Keio Univ. (Japan)


Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong; Nikiforos Kollias; Kenton W. Gregory; Henry Hirschberg; Reza S. Malek; Abraham Katzir; David S. Robinson; Kenneth Eugene Bartels; Eugene A. Trowers; Werner T.W. de Riese; Lawrence S. Bass; Lloyd P. Tate; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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