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Proceedings Paper

Measurement of refractive index variation of physiological analytes using differential-phase OCT
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Paper Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Paper Details

Date Published: 18 June 2004
PDF: 4 pages
Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); doi: 10.1117/12.532004
Show Author Affiliations
Kirill V. Larin, Univ. of Texas Medical Branch/Galveston (United States)
Taner Akkin, Univ. of Texas/Austin (United States)
Thomas E. Milner, Univ. of Texas/Austin (United States)
Digand P. Dave, Univ. of Texas/Austin (United States)
Massoud Motamedi, Univ. of Texas Medical Branch/Galveston (United States)
Rinat O. Esenaliev, Univ. of Texas Medical Branch/Galveston (United States)

Published in SPIE Proceedings Vol. 5325:
Optical Diagnostics and Sensing IV
Gerard L. Cote; Alexander V. Priezzhev, Editor(s)

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