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Proceedings Paper

Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: I. Acute wound closure study in a rat model
Author(s): Grant T. Hoffman; Eric C. Soller; Douglas L. Heintzelman; Mark T. Duffy; Jeffrey N. Bloom; Travis M. Gilmour; Krista N. Gonnerman; Karen M. McNally-Heintzelman
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Paper Abstract

Composite adhesives composed of biodegradable scaffolds impregnated with a biological or synthetic adhesive were investigated for use in wound closure as an alternative to using either one of the adhesives alone. Two different scaffold materials were investigated: (i) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ii) a biological material, small intestinal sub mucosa, manufactured by Cook BioTech. The biological adhesive was composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser. The synthetic adhesive was Ethicon's Dermabond, a 2-octyl-cyanoacrylate. The tensile strength of skin incisions repaired ex vivo in a rat model, by adhesive alone or in combination with a scaffold, as well as the time-to-failure, were measured and compared. The tensile strength of repairs formed using the scaffold-enhanced biological adhesives were on average, 80% stronger than their non-enhanced counterparts, with an accompanying increase in the time-to-failure of the repairs. These results support the theory that a scaffold material with an irregular surface that bridges the wound provides a stronger, more durable and consistent adhesion, due to the distribution of the tensile stress forces over the many micro-adhesions provided by the irregular surface, rather than the one large continuous adhesive contact. This theory is also supported by several previous ex vivo experiments demonstrating enhanced tensile strength of irregular versus smooth scaffold surfaces in identical tissue repairs performed on bovine thoracic aorta, liver, spleen, small intestine and lung tissue.

Paper Details

Date Published: 13 July 2004
PDF: 7 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.531991
Show Author Affiliations
Grant T. Hoffman, Rose-Hulman Institute of Technology (United States)
Eric C. Soller, Rose-Hulman Institute of Technology (United States)
Douglas L. Heintzelman, Advent Surgical Innovations, LLC (United States)
Massachusetts General Hospital (United States)
Mark T. Duffy, Advent Surgical Innovations, LLC (United States)
Univ. of Illinois College of Medicine (United States)
Jeffrey N. Bloom, Advent Surgical Innovations, LLC (United States)
Univ. of Illinois College of Medicine (United States)
Travis M. Gilmour, Rose-Hulman Institute of Technology (United States)
Krista N. Gonnerman, Rose-Hulman Institute of Technology (United States)
Karen M. McNally-Heintzelman, Rose-Hulman Institute of Technology (United States)
Advent Surgical Innovations, LLC (United States)


Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong; Nikiforos Kollias; Kenton W. Gregory; Henry Hirschberg; Reza S. Malek; Abraham Katzir; David S. Robinson; Kenneth Eugene Bartels; Eugene A. Trowers; Werner T.W. de Riese; Lawrence S. Bass; Lloyd P. Tate; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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