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Proceedings Paper

Singlet oxygen generation and dark toxicity of a nido- and a closo-carboranylporphyrin
Author(s): Maria Graca H. Vicente; Vijay Gottumukkala; Anura Wickramasinghe; Maxim Anikovsky; Michael A. J. Rodgers
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Paper Abstract

The dark toxicity and singlet oxygen quantum yields of the zinc(II) complexes of the nido- and closo-carboranylporphyrins 4 and 5 are reported. Both carboranylporphyrins show very low toxicity towards V79 hamster lung fibroblast cells (IC50 > 500 μM), display similar absorption and fluorescence emission spectra, and are efficient producers of singlet oxygen (quantum uilds of 0.72 in CD3OD and 0.45 in CHCl3 were determined for 4 and 5, respectively). Our results indicate that the presence of nido- or closo-carborane cages bound via methylene linkages to the meso-phenyl groups, do not substantially alter the photosensitizing properties of porphyrin macrocycles. It is suggested that carboanylporphyrins could have dual application in the boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) treatment of malignant brain tumors.

Paper Details

Date Published: 14 June 2004
PDF: 8 pages
Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); doi: 10.1117/12.531903
Show Author Affiliations
Maria Graca H. Vicente, Louisiana State Univ. (United States)
Vijay Gottumukkala, Louisiana State Univ. (United States)
Anura Wickramasinghe, Louisiana State Univ. (United States)
Maxim Anikovsky, Bowling Green State Univ. (United States)
Michael A. J. Rodgers, Bowling Green State Univ. (United States)


Published in SPIE Proceedings Vol. 5315:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII
David Kessel, Editor(s)

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