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Proceedings Paper

Cell/surface interactions on laser-micro-textured titanium-coated silicon surfaces
Author(s): Steven Mwenifumbo; Mingwei Li; Wole Soboyejo
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Paper Abstract

This paper presents the results of recent efforts to improve the biocompatibility and integration of implantable bioMEMS devices. Laser micro-grooves and micro-grids were irradiated onto silicon surfaces using ultraviolet lasers. The micro-textured surfaces were then coated with nano-scale layers of titanium to promote improved biocompatibility. The micro-groove geometries have been shown to promote contact guidance, which leads to reduced scar tissue formation. In contrast, smooth surfaces result in random cell orientations and the increased possibility of scar tissue formation. The nature of the cellular attachment and adhesion to the coated/uncoated micro-textured surfaces was elucidated by the visualization of the cells through scanning electron microscopy. Finally, the implications of the results are discussed for integration of silicon-based microelectronics and sensors into biological systems.

Paper Details

Date Published: 15 July 2004
PDF: 12 pages
Proc. SPIE 5339, Photon Processing in Microelectronics and Photonics III, (15 July 2004); doi: 10.1117/12.531643
Show Author Affiliations
Steven Mwenifumbo, Princeton Univ. (United States)
Mingwei Li, Spectra-Physics, Inc. (United States)
Wole Soboyejo, Princeton Univ. (United States)


Published in SPIE Proceedings Vol. 5339:
Photon Processing in Microelectronics and Photonics III
Jan J. Dubowski; Peter R. Herman; Friedrich G. Bachmann; Willem Hoving; Jim Fieret; David B. Geohegan; Frank Träger; Kunihiko Washio; Alberto Pique; Xianfan Xu; Tatsuo Okada, Editor(s)

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