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Proceedings Paper

Nonlinear-optical photothermal modification of collagen
Author(s): V. Shcheslavskiy; R. D. Heathcote; Vladislav V. Yakovlev
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Paper Abstract

We report on a novel mechanism of tissue modification. We demonstrate that if the train of ultrashort laser pulses has sufficient average power, multiphoton absorption can result in a significant heating of a localized area of a collagen-rich tissue leading to its photothermal modification. We propose a simple model describing the effect of local heating and derive a simple way of estimating the contribution of this mechanism for different parameters of incident radiation. Microscopic confocal imaging studies complement the spectroscopic studies to ensure the minimal destruction of surrounding areas of a tissue.

Paper Details

Date Published: 1 July 2004
PDF: 7 pages
Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); doi: 10.1117/12.531629
Show Author Affiliations
V. Shcheslavskiy, Univ. of Wisconsin/Milwaukee (United States)
R. D. Heathcote, Univ. of Wisconsin/Milwaukee (United States)
Vladislav V. Yakovlev, Univ. of Wisconsin/Milwaukee (United States)

Published in SPIE Proceedings Vol. 5319:
Laser Interaction with Tissue and Cells XV
Steven L. Jacques; William P. Roach, Editor(s)

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