Share Email Print
cover

Proceedings Paper

Protein-based molecular contrast optical coherence tomography
Author(s): Changhuei Yang; Michael A. Choma; Laura E. Lamb; John D. Simon; Joseph A. Izatt
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) which uses optically switchable protein based chromophores. Photosensitive proteins, such as bacteriorhodopsin and phytochrome, are promising OCT molecular contrast agents by reason of their remarkably low transition activation intensities compatible with in vivo imaging, and their potential for use as genetically expressible markers for molecular imaging. This study details the use of a novel optical switch suppression scheme which uses the absorption change between the two state groups of phytochrome to extract concentration and distribution information of the contrast agent within a target sample.

Paper Details

Date Published: 1 July 2004
PDF: 6 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.531353
Show Author Affiliations
Changhuei Yang, Duke Univ. (United States)
Michael A. Choma, Duke Univ. (United States)
Laura E. Lamb, Duke Univ. (United States)
John D. Simon, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

© SPIE. Terms of Use
Back to Top