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Proceedings Paper

Applicability of photoacoustic measurement for biomechanical characterization: from in vitro engineered tissue characterization to in vivo diagnosis
Author(s): Miya Ishihara; Masato Sato; Shunichi Sato; Toshiyuki Kikuchi; Masayuki Ishihara; Joji Mochida; Kyosuke Fujikawa; Makoto Kikuchi
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Paper Abstract

We demonstrated a capability of biomechanical characterization by photoacoustic measurement for the purpose of non-invasive functional evaluation of articular cartilage. In this study, the scheme of photoacoustic measurement was improved. For in vivo application, the measurement scheme was changed from a transmittance mode to a reflectance mode in which an optical fiber was coaxially arranged with a piezoelectric transducer. In order to verify the applicability of this measurement for diagnosis of cartilage degeneration, photoacoustic measurements in a reflectance mode were performed using various degenerated cartilages. As a model of degenerated cartilage, cartilage-bone plugs were punched out from a porcine knee joint and treated with trypsin (1 mg/ml). Stress waves were induced by 250-355 nm, 7-ns light pulses delivered through an optical silica fiber from an OPO and were detected by a piezoelectric transducer. The change in relaxation time, which was correlated with the viscosity-elasticity ratio, had a positive correlation with time of trypsin treatment. Our results revealed the applicability of photoacoustic measurement to in vivo preoperative diagnosis of cartilage degeneration.

Paper Details

Date Published: 1 July 2004
PDF: 4 pages
Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); doi: 10.1117/12.530527
Show Author Affiliations
Miya Ishihara, National Defense Medical College (Japan)
Masato Sato, Tokai Univ. School of Medicine (Japan)
Shunichi Sato, National Defense Medical College (Japan)
Toshiyuki Kikuchi, National Defense Medical College (Japan)
Masayuki Ishihara, National Defense Medical College (Japan)
Joji Mochida, Tokai Univ. School of Medicine (Japan)
Kyosuke Fujikawa, National Defense Medical College (Japan)
Makoto Kikuchi, National Defense Medical College (Japan)

Published in SPIE Proceedings Vol. 5319:
Laser Interaction with Tissue and Cells XV
Steven L. Jacques; William P. Roach, Editor(s)

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