Share Email Print
cover

Proceedings Paper

Stimulation of the host immune response by photodynamic therapy (PDT)
Author(s): Sandra O. Gollnick; Edith Kabingu; Philaretos C. Kousis; Barbara W. Henderson
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

The tumor response to photodynamic therapy (PDT) involves a complex interplay between direct cytotoxicity to the tumor cells and secondary damage as a result of the effects of PDT on the vasculature and stimulation of the host inflammatory response. Pre-clinical and clinical studies have suggested that the combination of direct and indirect effects of PDT culminate in an activation of host anti-tumor immune responses. We have begun to examine the direct effects of PDT on tumor immunogenicity and have made the novel discovery that PDT treatment of tumor cells in vitro enhances tumor cell immunogenicity. We have further demonstrated that the increase in tumor cell immunogenicity by PDT can be correlated with the ability of PDT-generated tumor cell lysates to stimulate dendritic cell maturation and activation. The mechanisms by which PDT is able to enhance tumor cell immunogenicity and stimulate dendritic cell maturation and activation is unclear, however our finding suggest that alterations in tumor immunogenicity correlate with enhanced release of dendritic cell stimulating factors such as heat shock proteins.

Paper Details

Date Published: 1 July 2004
PDF: 11 pages
Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); doi: 10.1117/12.530437
Show Author Affiliations
Sandra O. Gollnick, Roswell Park Cancer Institute (United States)
Edith Kabingu, Roswell Park Cancer Institute (United States)
Philaretos C. Kousis, Roswell Park Cancer Institute (United States)
Barbara W. Henderson, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 5319:
Laser Interaction with Tissue and Cells XV
Steven L. Jacques; William P. Roach, Editor(s)

© SPIE. Terms of Use
Back to Top