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Proceedings Paper

In vivo OCT study of neoplastic alterations of the oral cavity mucosa
Author(s): Julia Valer'evna Fomina; Natalia D. Gladkova; Ludmila B. Snopova; Natalia M. Shakhova; Felix I. Feldchtein; Alexey V. Myakov
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Paper Abstract

The goal of our study was to conduct a statistical evaluation of the ability of optical coherence tomography (OCT) to detect neoplasia in vivo in oral cavity. The study enrolled 97 patients (35 volunteers with healthy mucosa of the oral cavity-group I, 41 patients with benign conditions-group II, 21 patients with dysplasia or carcinoma-group III). The diagnosis was established by a histopathology examination of biopsy material. Each biopsy site was imaged by OCT beforehand. Sensitivity of 83% and specificity of 98% were observed as a result of OCT image recognition of dysplastic/malignant versus benign/reactive conditions in the oral cavity. The interobserver agreement kappa was 0.76. Such sensitivity and specificity makes OCT a promising tool for non-invasive evaluation of tissue sites suspicious for high-grade dysplasia and cancer.

Paper Details

Date Published: 1 July 2004
PDF: 7 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.530412
Show Author Affiliations
Julia Valer'evna Fomina, Nizhny Novgorod Medical Academy (Russia)
Natalia D. Gladkova, Nizhny Novgorod Medical Academy (Russia)
Ludmila B. Snopova, Nizhny Novgorod Medical Academy (Russia)
Natalia M. Shakhova, Institute of Applied Physics (Russia)
Felix I. Feldchtein, Institute of Applied Physics (Russia)
Imalux Corp. (United States)
Alexey V. Myakov, Institute of Applied Physics (Russia)


Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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