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Proceedings Paper

Simulations at a newly derived reference model of the human lung
Author(s): Andres Kriete; Andreas H Schmidt; Stephan Zidowitz; Daniel C Haworth; Robert F Kunz
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Paper Abstract

Based on an in-vitro preparation of an adult human lung combined with high-resolution tomography we developed a realistic graph representation of the bronchial tree of a particular human lung. The graph contains topological information about spatial coordinates, connectivities, diameters and branching angles of 1453 bronchi up to the 17th Horsfield order, and is characterized by asymmetric and multifractal properties. This geometrical model was the basis for the development of an unstructured, multiphase CFD model of the trachea and upper airways. This is directly relevant to research in that intricate anatomical system geometries are employed. Based on medical imaging data CFD modeling associated with complex moving geometries, multi-phase/multi-species physics, and turbulence is incorporated. We contrast this approach with the use of mass-transport equations that describe the gas transport axially. Results show that many of the transport processes within the airways depend quite sensitively on the geometry of the bronchial bifurcations and the structure of the boundaries.

Paper Details

Date Published: 1 July 2004
PDF: 7 pages
Proc. SPIE 5318, Advanced Biomedical and Clinical Diagnostic Systems II, (1 July 2004); doi: 10.1117/12.530332
Show Author Affiliations
Andres Kriete, Institute of Anatomy and Cell Biology (Germany)
Drexel Univ. (United States)
Andreas H Schmidt, Institute of Anatomy and Cell Biology (Germany)
Stephan Zidowitz, Ctr. for Medical Diagnostic Systems and Visualization (Germany)
Daniel C Haworth, The Pennsylvania State Univ. (United States)
Robert F Kunz, The Pennsylvania State Univ. (United States)


Published in SPIE Proceedings Vol. 5318:
Advanced Biomedical and Clinical Diagnostic Systems II
Gerald E. Cohn; Warren S. Grundfest; David A. Benaron; Tuan Vo-Dinh, Editor(s)

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