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Proceedings Paper

Interaction of motor proteins of various types at melanosome redistribution in melanocytes under action of UV radiation
Author(s): Mikhail M. Stolnitz; Alexey A Kudryashov
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Paper Abstract

In the report the mathematical model of melanosome transport along filaments in intact and UV-irradiated melanocytes is submitted. Processes at three levels are considered: dynamics of the single motor, transport of melanosome by ensemble of motors, and melanosomes distribution along microtubules. A single motor is considered as <<stochastic ratchet>>; modeling of transitions between internal states described by chemical kinetics equations allows to determine "force-velocity" dependence for motor. The ensemble of motors is described by system of equations for average motor velocities, and transported melanosome moves with average velocity, which in turn is determined by sum of force generated by each elastic-coupled motor (self-consistence problem). Distribution of melanosomes along a microtubule is described by system of equations for bidirectional motion of attached melanosome under coordinated action of "plus-end" and "minus-end" motors and free diffusion of unattached melanosomes. Influence of UV-radiation is resulted in change of number of each type motors simultaneously linked to one melanosome. It induces redistribution of melanosomes between centre and periphery of melanocyte.

Paper Details

Date Published: 28 May 2004
PDF: 9 pages
Proc. SPIE 5330, Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics, (28 May 2004); doi: 10.1117/12.530293
Show Author Affiliations
Mikhail M. Stolnitz, Saratov State Univ. (Russia)
Alexey A Kudryashov, Municipal Clinical Hospital No. 2 (Russia)

Published in SPIE Proceedings Vol. 5330:
Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics
Valery V. Tuchin, Editor(s)

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