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Proceedings Paper

A compact surface plasmon resonance and surface-enhanced Raman scattering sensing device
Author(s): Jenq-Nan Yih; Shean-Jen Chen; Kun-Tsai Huang; Y.-T. Su; G.-Y. Lin
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Paper Abstract

This paper presents an optical device capable of the simultaneous measurement of the surface plasmon resonance (SPR) spectrum, which provides information regarding the change in the dielectric constant of the binding analytes, and the surface-enhanced Raman scattering (SERS) spectrum, which yields analytical data regarding the structural changes of the analytes. SPR sensing is an established technology in the field of direct real-time analysis of biomolecular interactions such as antibodies/antigens, DNA hybridization, receptors/ligands, etc. Meanwhile, SERS sensing techniques represent a powerful means of acquiring and diagnosing structural information relating to analyte binding. This study adopts the attenuated total reflection (ATR) method and an Au nanocluster-embedded dielectric sensing film in developing a biosensor which integrates the SPR and SERS sensing techniques. The results confirm the effectiveness of the proposed multi-functional device in developing a detailed understanding of the mechanisms of biomolecular recognition.

Paper Details

Date Published: 16 June 2004
PDF: 5 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.530246
Show Author Affiliations
Jenq-Nan Yih, National Central Univ. (Taiwan)
Shean-Jen Chen, National Cheng Kung Univ. (Taiwan)
Kun-Tsai Huang, National Central Univ. (Taiwan)
Y.-T. Su, National Central Univ. (Taiwan)
G.-Y. Lin, National Central Univ. (Taiwan)


Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)

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