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Proceedings Paper

POISe: pulsed optoacoustic interferometric spectroscopy and imaging
Author(s): Stefan A. Carp; Arnold Guerra III; Samuel Quiba Duque Jr.; Vasan Venugopalan
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Paper Abstract

POISe is a spectroscopic imaging technique based on the measurement of surface motion resulting from thermoelastic stress waves produced by short pulse laser irradiation of optically heterogeneous turbid samples. Here we show the capability of POISe to form tomographic images of tissue phantoms using surface displacement measurements taken at several locations following irradiation of a sample with a Q-switched Nd:YAG laser λ=1064 nm. The principal component of POISe is a modified Mach-Zehnder interferometer that provides surface displacement measurements with a temporal resolution of 4 ns and a displacement sensitivity of 0.2 nm. By performing simple image reconstructions on data sets acquired from several tissue-like phantoms, we demonstrate the ability of POISe to provide better than 250 μm spatial resolution at depths of 6 to 8 mm in a strongly scattering medium (μ's=1/mm). This technique shows great promise for high-resolution non-invasive imaging of superficial (< 1 cm) tissue structures.

Paper Details

Date Published: 12 July 2004
PDF: 8 pages
Proc. SPIE 5320, Photons Plus Ultrasound: Imaging and Sensing, (12 July 2004); doi: 10.1117/12.529675
Show Author Affiliations
Stefan A. Carp, Univ. of California/Irvine (United States)
Arnold Guerra III, Univ. of California/Irvine (United States)
Samuel Quiba Duque Jr., Univ. of California/Irvine (United States)
Vasan Venugopalan, Univ. of California/Irvine (United States)

Published in SPIE Proceedings Vol. 5320:
Photons Plus Ultrasound: Imaging and Sensing
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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