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Proceedings Paper

Birefringence measurements in human skin using polarization-sensitive optical coherence tomography
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Paper Abstract

Optical coherence tomography enables cross-sectional imaging of tissue structure to depths of around 1.5 mm, at high-resolution and in real-time. Incorporation of polarization-sensitivity enables the birefringent properties of tissues to be visualized and quantified. We present polarization-sensitive optical coherence tomography images and quantitative birefringence analysis of in vivo human skin. From measurements on a sample of 5 human volunteers, mean double-pass phase retardation rates of 0.340 ± 0.143, 0.250 ± 0.076 and 0.592 ± 0.142°/μm were obtained for normal skin at the dorsal hand, temple and lower back regions respectively. Compared to these values measured in normal skin, a reduction in birefringence was observed and quantified in human skin following thermal injury. Conversely, increased birefringence was consistently measured at skin sites following wound healing and repair.

Paper Details

Date Published: 13 July 2004
PDF: 6 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.529627
Show Author Affiliations
Mark C. Pierce, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard Medical School (United States)
John Strasswimmer, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard Medical School (United States)
B. Hyle Park, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard Medical School (United States)
Barry Cense, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard Medical School (United States)
Johannes F. de Boer, Wellman Ctr. for Photomedicine, Massachusetts General Hospital and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong; Nikiforos Kollias; Kenton W. Gregory; Henry Hirschberg; Reza S. Malek; Abraham Katzir; David S. Robinson; Kenneth Eugene Bartels; Eugene A. Trowers; Werner T.W. de Riese; Lawrence S. Bass; Lloyd P. Tate; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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