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Proceedings Paper

Spectroscopic monitoring of kidney tissue ischemic injury
Author(s): Jason T. Fitzgerald; Andromachi P. Michalopoulou; Christoph Troppmann; Stavros G. Demos
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Paper Abstract

Noninvasive evaluation of tissue viability of donor kidneys used for transplantation is an issue that current technology is not able to address. In this work, we explore optical spectroscopy for its potential to assess the degree of ischemic damage in kidney tissue. We hypothesized that ischemic damage to kidney tissue will give rise to changes in its optical properties which in turn may be used to asses the degree of tissue injury. The experimental results demonstrate that the autofluorescence intensity of the injured kidney is decreasing as a function of time exposed to ischemic injury. Changes were also observed in the NIR light scattering intensities most probably arising from changes due to injury and death of the tissue.

Paper Details

Date Published: 13 July 2004
PDF: 5 pages
Proc. SPIE 5326, Optical Biopsy V, (13 July 2004); doi: 10.1117/12.529284
Show Author Affiliations
Jason T. Fitzgerald, Univ. of California/Davis Medical Ctr. (United States)
Andromachi P. Michalopoulou, Univ. of California/Davis Medical Ctr. (United States)
Christoph Troppmann, Univ. of California/Davis Medical Ctr. (United States)
Stavros G. Demos, Lawrence Livermore National Lab. (United States)
Univ. of California/David Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 5326:
Optical Biopsy V
Robert R. Alfano; Alvin Katz, Editor(s)

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