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Proceedings Paper

A fiber optic approach for in vivo minimally invasive study of tissue optical properties
Author(s): Ilko K. Ilev; Ronald W Waynant; Kimberly R Byrnes; Juanita Anders
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Paper Abstract

Based on a fiber-optic approach, we present a fundamental in vivo study of optical properties and light transmission characteristics of single and multiple tissue layers and blood in a Sprague Dawley rat model. In our experiments, we utilize either coherent laser sources with various energy and spectral characteristics or incoherent light sources in a broadband spectral range covering the visible and near-infrared (from 400 nm to 1200 nm). The measurement techniques are based on a simple minimally invasive fiber-optic light delivery system that provides an effective method for homogeneously and precisely controlling the light irradiation of the tissue medium as well as being a highly sensitive detector of the tissue's scattered light. The delivery-sensor probes are placed into different tissue layers (skin, sub-cutaneous connective and deep connective tissue, back muscle, bone and spinal cord) and blood, and broadband spectral transmission characteristics of these media are measured in vivo. The transmission spectra are analyzed in order to determine the specificity of interaction of different tissues with light. The main goal is to determine the most effective coherent or incoherent light sources and their optimal parameters that might be used for minimally invasive therapeutic and optical diagnostics techniques.

Paper Details

Date Published: 10 June 2004
PDF: 4 pages
Proc. SPIE 5317, Optical Fibers and Sensors for Medical Applications IV, (10 June 2004); doi: 10.1117/12.529159
Show Author Affiliations
Ilko K. Ilev, U.S. Food and Drug Administration (United States)
Ronald W Waynant, U.S. Food and Drug Administration (United States)
Kimberly R Byrnes, Uniformed Services Univ. of the Health Sciences (United States)
Juanita Anders, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 5317:
Optical Fibers and Sensors for Medical Applications IV
Israel Gannot, Editor(s)

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