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Proceedings Paper

Agile optical confocal microscopy instrument architectures for high flexibility imaging
Author(s): Nabeel Agha Riza; Amana Bokhari
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Paper Abstract

Ideally, a no-moving parts fast and agile scanning confocal microscope system is required that can produce true real-time 3-D scans with precision and repeatability. In this paper, such agile optical confocal microsopy designs are proposed that enable high speed precise non-invasive 3-D imaging. These compact confocal microscopes can provide real-time pin-point focussed imaging to enable confocal slices in-vivo, thus greatly reducing motion artifacts. These microscopes can be modified into interferometric microscopes for phase contrast imaging. The proposed microscopes can also greatly improve confocal fluorescence imaging as needed for cancer detection. An ultracompact confocal probe tip connected to a single ultra-thin fiber is another design option allowing flexibility for usage in tight cavities.

Paper Details

Date Published: 13 July 2004
PDF: 12 pages
Proc. SPIE 5324, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XI, (13 July 2004); doi: 10.1117/12.529073
Show Author Affiliations
Nabeel Agha Riza, Nuonics, Inc. (United States)
Amana Bokhari, Nuonics, Inc. (United States)


Published in SPIE Proceedings Vol. 5324:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XI
Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson, Editor(s)

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