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Proceedings Paper

Infrared fiber optic spectroscopy: a novel tool for skin diagnosis
Author(s): Ilan Goldberg; Aushrat Shushan; Sarah Brenner; Boaz Nadler; Yosef Raichlin; Evgeny Shulzinger; Leah Gerber; Abraham Katzir
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Paper Abstract

Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBrxCl1-x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.

Paper Details

Date Published: 1 July 2004
PDF: 7 pages
Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); doi: 10.1117/12.528961
Show Author Affiliations
Ilan Goldberg, Tel Aviv Sourasky Medical Ctr. (Israel)
Aushrat Shushan, Tel Aviv Sourasky Medical Ctr. (Israel)
Sarah Brenner, Tel Aviv Sourasky Medical Ctr. (Israel)
Boaz Nadler, Yale Univ. (United States)
Yosef Raichlin, College of Judea and Samaria (Israel)
Evgeny Shulzinger, Tel Aviv Univ. (Israel)
Leah Gerber, Tel Aviv Univ. (Israel)
Abraham Katzir, Tel Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 5321:
Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies
Zygmunt Gryczynski; Anita Mahadevan-Jansen; Michael G. Sowa; Tuan Vo-Dinh; Joseph R. Lakowicz; Gerwin J. Puppels, Editor(s)

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