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Proceedings Paper

Urological applications of Raman spectroscopy for improved malignant diagnostics
Author(s): M. Consuelo Hart Prieto; Paul Crow; Catherine Kendall; Jeremy Uff; Mark Wright; Alistair Ritchie; Nicholas Stone
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Paper Abstract

The incidence of both prostate and bladder cancer is high; prostate cancer being the most frequently diagnosed non-cutaneous cancer affecting Western men. At present the gold standard for diagnosis of pathologies within the bladder and the prostate gland is by means of histological examination of biopsies. This is a subjective means of examining tissue and has an element of both inter and intra-observer variability. A large number of specimens have been collected and analysed using both a NIR-Raman spectrometer and histopathology with H&E staining. Multivariate spectral prediction models have been constructed and tested. An evaluation of misclassification cost models and the use of cancer staging data to train the models has been made.

Paper Details

Date Published: 1 July 2004
PDF: 12 pages
Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); doi: 10.1117/12.528907
Show Author Affiliations
M. Consuelo Hart Prieto, Gloucestershire Royal Hospital (United Kingdom)
Paul Crow, Gloucestershire Royal Hospital (United Kingdom)
Catherine Kendall, Gloucestershire Royal Hospital (United Kingdom)
Jeremy Uff, Gloucestershire Royal Hospital (United Kingdom)
Mark Wright, Gloucestershire Royal Hospital (United Kingdom)
Alistair Ritchie, Gloucestershire Royal Hospital (United Kingdom)
Nicholas Stone, Gloucestershire Royal Hospital (United Kingdom)


Published in SPIE Proceedings Vol. 5321:
Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies
Zygmunt Gryczynski; Anita Mahadevan-Jansen; Michael G. Sowa; Tuan Vo-Dinh; Joseph R. Lakowicz; Gerwin J. Puppels, Editor(s)

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