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Proceedings Paper

Chemiluminescence detection of reactive oxygen species during photodynamic therapy
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Paper Abstract

Photodynamic therapy (PDT) utilizes photon energy to activate a pre-administered photosensitizer drug in tissue to achieve a localized tumor control. PDT cell killing mechanism is directly related to the reactive oxygen species (ROS) produced during the photochemical reactions. Conventional PDT dosimetry evaluates distributions of the photosensitizer drug, photon propagation and absorption, and availability of molecular oxygen in the target tissue. Yet, the ultimate bullet for the damaging effect is ROS. An evaluation of ROS production during PDT should provide a more direct marker for PDT. Fluoresceinyl Cypridina Luciferin Analog (FCLA) is a chemiluminescence probe that specifically interacts with ROS (singlet oxygen and/or superoxide). The work is a preliminary investigation of the feasibility using FCLA as a means to evaluate ROS production in PDT.

Paper Details

Date Published: 14 June 2004
PDF: 7 pages
Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); doi: 10.1117/12.528576
Show Author Affiliations
Da Xing, South China Normal Univ. (China)
Yanfang Qin, Ji Nan Univ. (China)
Yunxia Wu, South China Normal Univ. (China)
Jin Zhou, South China Normal Univ. (China)
Shiming Luo, South China Normal Univ. (China)
Yonghong He, South China Normal Univ. (China)
Qun Chen, South China Normal Univ. (China)
HealthONE Alliance (United States)


Published in SPIE Proceedings Vol. 5315:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII
David Kessel, Editor(s)

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