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Proceedings Paper

Biosensing based upon molecular confinement in metallic nanocavities
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Paper Abstract

We describe the basis for an affinity biosensor platform in which enhanced fluorescence transduction occurs through the optical excitation of molecules located within metallic nanocavities. These nanocavities are about 200 nm in diameter and are arranged in a periodic or random two-dimensional (2D) arrays, which are fabricated in 70 nm-thick gold films by e-beam lithography using negative e-beam resist. The experimental results show that both periodic and randomly placed metallic nanoapertures can be used to enhance the output of a fluorescing molecular monolayer by more than a factor of 10.

Paper Details

Date Published: 1 June 2004
PDF: 8 pages
Proc. SPIE 5331, Nanobiophotonics and Biomedical Applications, (1 June 2004); doi: 10.1117/12.528335
Show Author Affiliations
Yongdong Liu, Univ. of Utah (United States)
Steve Blair, Univ. of Utah (United States)

Published in SPIE Proceedings Vol. 5331:
Nanobiophotonics and Biomedical Applications
Alexander N. Cartwright, Editor(s)

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