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Proceedings Paper

Evaluation of the analgesic effect of low-power optical radiation in acute inflammatory process
Author(s): Denise Maciel Ferreira; Renato Amaro Zangaro; Yara Cury; Lucio Frigo; Daniella Galvao Barbosa; Milene da Silva Melo; Egberto Munin
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Paper Abstract

Many research works have explored the use of the low power laser as a tool for the control of inflammatory processes. The anti-inflammatory effect of low power optical radiation and its ability to induce analgesia has been reported for different experimental conditions. Many published works are very qualitative in nature. In this work the action of low power laser radiation on acute inflammatory process is evaluated. The time evolution of rat paw edema and pain induced by carrageenan was experimentally monitored. A 632.8 nm He-Ne laser was used for the treatment. The laser treatment, at a dosage of 2,5 J/cm2, was applied at the first, second and third hour after the induction of the inflammation. A hydroplethysmometer was used for the evaluation of the inflammation. The measurement of pain sensitivity was performed according to the method described by Randall and Selito, (1957). The laser treatment was capable of inhibiting the carrageenan-induced hyperalgesia by 49% (p<0,001) at the second hour after the induction, as compared to the non-treated group. At the fourth hour (peak of the carrageenan action on hyperalgesia) and at the sixth hour, the achieved inhibition was 49% (p<0,001) and 61% (p<0,001), respectively. In the treated groups, the edema evolution was inhibited by 38% (p<0,01), at the second hour after induction, as compared to the non-treated groups. At the fourth hour (peak of the carrageenan action on leakage) and at sixth hour the achieved inhibition was 35% (p<0,01) and 30% (p<0,05) respectively.

Paper Details

Date Published: 1 July 2004
PDF: 5 pages
Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); doi: 10.1117/12.528250
Show Author Affiliations
Denise Maciel Ferreira, Univ. do Vale do Paraiba (Brazil)
Renato Amaro Zangaro, Univ. do Vale do Paraiba (Brazil)
Yara Cury, Instituto Butantan (Brazil)
Lucio Frigo, Univ. do Vale do Paraiba (Brazil)
Daniella Galvao Barbosa, Univ. do Vale do Paraiba (Brazil)
Milene da Silva Melo, Univ. do Vale do Paraiba (Brazil)
Egberto Munin, Univ. do Vale do Paraiba (Brazil)


Published in SPIE Proceedings Vol. 5319:
Laser Interaction with Tissue and Cells XV
Steven L. Jacques; William P. Roach, Editor(s)

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