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Proceedings Paper

In vitro osteosarcoma biosensing using THz time domain spectroscopy
Author(s): Bradley S. Ferguson; Haibo Liu; Shelley Hay; David Findlay; Xi-Cheng Zhang; Derek Abbott
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Paper Abstract

Terahertz time domain spectroscopy (THz-TDS) has a wide range of applications from semiconductor diagnostics to biosensing. Recent attention has focused on bio-applications and several groups have noted the ability of THz-TDS to differentiate basal cell carcinoma tissue from healthy dermal tissue ex vivo. The contrast mechanism is unclear but has been attributed to increased interstitial water in cancerous tissue. In this work we investigate the THz response of human osteosarcoma cells and normal human bone cells grown in culture to isolate the cells' responses from other effects. A classification algorithms based on a frequency selection by genetic algorithm is used to attempt to differentiate between the cell types based on the THz spectra. Encouraging preliminary results have been obtained.

Paper Details

Date Published: 29 March 2004
PDF: 13 pages
Proc. SPIE 5275, BioMEMS and Nanotechnology, (29 March 2004); doi: 10.1117/12.527880
Show Author Affiliations
Bradley S. Ferguson, Rensselar Polytechnic Institute (United States)
The Univ. of Adelaide (Australia)
CRC for Sensor, Signal, and Information Processing (Australia)
Haibo Liu, Rensselaer Polytechnic Institute (United States)
Shelley Hay, The Univ. of Adelaide (Australia)
David Findlay, The Univ. of Adelaide (Australia)
Xi-Cheng Zhang, Rensselaer Polytechnic Institute (United States)
Derek Abbott, The Univ. of Adelaide (Australia)

Published in SPIE Proceedings Vol. 5275:
BioMEMS and Nanotechnology
Dan V. Nicolau; Uwe R. Muller; John M. Dell, Editor(s)

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