Share Email Print
cover

Proceedings Paper

Doppler optical coherence tomography for monitoring the vascular effects of photodynamic therapy
Author(s): Maggie L. Gordon; Victor X. D. Yang; Emily Seng Yue; Stewart S. W. Lo; Brian C. Wilson; I. Alex Vitkin
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Doppler optical coherence tomography (DOCT) is a powerful tool for providing not only subsurface microstructural, but also functional information. Our group's system is able to image blood vessels as small as ~ 30 μm in diameter, with blood flows as slow as ~ 20 μm/s. Photodynamic therapy (PDT), once a "novel" cancer treatment, is now a major research field in biophotonics and is gaining clinical popularity. The highly sensitive DOCT system was used to image microcirculation in normal rat colon and a rat prostate cancer model before, during, and after PDT. The results demonstrate that DOCT can monitor the vascular changes during PDT and that DOCT can highlight the differences in tissue response with different treatment protocols. Furthermore, DOCT demonstrated differences in response between normal and cancerous tissues.

Paper Details

Date Published: 1 July 2004
PDF: 8 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.527794
Show Author Affiliations
Maggie L. Gordon, Univ. of Toronto (Canada)
Victor X. D. Yang, Univ. of Toronto (Canada)
Emily Seng Yue, Ontario Cancer Institute, Princess Margaret Hospital/University Health Network (Canada)
Stewart S. W. Lo, Ontario Cancer Institute, Princess Margaret Hospital/University Health Network (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
and Ontario Cancer Institute, Princess Margaret Hospital/University Health Network (Canada)
Photonics Research Ontario (Canada)
I. Alex Vitkin, Univ. of Toronto (Canada)
Ontario Cancer Institute, Princess Margaret Hospital/University Health Network (United States)


Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

© SPIE. Terms of Use
Back to Top