Share Email Print
cover

Proceedings Paper

Synthesis and photodynamic activities of modified benzochlorin derivatives on nasopharyngeal carcinoma cells
Author(s): Chi K. Chang; Yan-Kin Lau; Tat-Shing Lai; Lam-Lung Yeung; Wing-Nang Leung; Nai-Ki Mak
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Nasopharyngeal carcinoma (NPC), endemic in Southern China, is ranked as the fourth leading cause of cancer deaths in Hong Kong. In an effort to develop new PDT agents for cancer treatment, with a particular emphasis on the NPC, we have investigated the benzochlorin-type photosensitizers. The chromophore is functionalized with side chains containing polar and/or cationic groups. Synthetic methods have been developed for such purposes; e.g. 5-chlorosulfonyloctaethylbenzochlorin and 5-bromooctaethylbenzochlorin are used as versatile precursors for the preparation of ammonium and amidinium salts. Preliminary in vitro study of the photodynamic activity of the synthetic compounds indicated that the cationic benzochlorin derivatives display significant photocytotoxicity towards NPC cells.

Paper Details

Date Published: 14 June 2004
PDF: 12 pages
Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); doi: 10.1117/12.527557
Show Author Affiliations
Chi K. Chang, Hong Kong Univ. of Science and Technology (Hong Kong China)
Yan-Kin Lau, Hong Kong Univ. of Science and Technology (Hong Kong China)
Tat-Shing Lai, Hong Kong Univ. of Science and Technology (Hong Kong China)
Lam-Lung Yeung, Hong Kong Univ. of Science and Technology (Hong Kong China)
Wing-Nang Leung, Hong Kong Baptist Univ. (Hong Kong China)
Nai-Ki Mak, Hong Kong Baptist Univ. (Hong Kong China)


Published in SPIE Proceedings Vol. 5315:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII
David Kessel, Editor(s)

© SPIE. Terms of Use
Back to Top