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Proceedings Paper

Optical biosensor based on localized surface plasmon resonance with high spatial resolution
Author(s): Xin Hong; Fu-Jen Kao
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Paper Abstract

We are using a gold nanoparticle coated film to achieve high spatially resolved biosensing that is based on localized surface plasmon resonance (LSPR). This special film possesses the unique optical properties of being not sensitive to the changes of incident angle and relies exclusively on the spectral shift of absorption peak for biosensing. This uniqueness enables it to be compatible with high numerical aperture (NA) optics and to achieve high spatial resolution. We demonstrate a spatial resolution of 25μm assuming a maximum of spectral fluctuation of 0.1nm is acceptable.

Paper Details

Date Published: 16 June 2004
PDF: 7 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.525962
Show Author Affiliations
Xin Hong, Tianjin Univ. (China)
National Sun Yat-Sen Univ. (Taiwan)
Fu-Jen Kao, Tianjin Univ. (China)
National Sun Yat-Sen Univ. (Taiwan)

Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)

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