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Proceedings Paper

Automatic quantification of neurite outgrowth by means of image analysis
Author(s): Gert Van de Wouwer; Rony Nuydens; Theo Meert; Barbara Weyn
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Paper Abstract

A system for quantification of neurite outgrowth in in-vitro experiments is described. The system is developed for routine use in a high-throughput setting and is therefore needs fast, cheap, and robust. It relies on automated digital microscopical imaging of microtiter plates. Image analysis is applied to extract features for characterisation of neurite outgrowth. The system is tested in a dose-response experiment on PC12 cells + Taxol. The performance of the system and its ability to measure changes on neuronal morphology is studied.

Paper Details

Date Published: 13 July 2004
PDF: 7 pages
Proc. SPIE 5324, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XI, (13 July 2004); doi: 10.1117/12.525634
Show Author Affiliations
Gert Van de Wouwer, Univ. of Antwerp (Belgium)
Digital Cell Imaging Labs (Belgium)
Rony Nuydens, Janssen Pharmaceutica N.V. (Belgium)
Theo Meert, Janssen Pharmaceutica N.V. (Belgium)
Barbara Weyn, Univ. of Antwerp (Belgium)
Digital Cell Imaging Labs (Belgium)


Published in SPIE Proceedings Vol. 5324:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XI
Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson, Editor(s)

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