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Proceedings Paper

Femtoliter micro-injector using digital microfluidic control
Author(s): Weiyi Zhang; Liya Hou; Lili Mu; Li Zhu
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Paper Abstract

This paper presents a novel micro injector, by which microfluidic delivery, transport and control can be digitally realized in femtoliter scale. The microinjection is based on a new principle that the micropipette is actuated by an actuator, which is located outside the micropipette and may have macro scale dimensions, moving in such a manner that its acceleration changes. When the acceleration is small, the liquid moves along with the pipette; while, when the acceleration becomes large enough, the liquid flows relative to the micropipette. The validity of the presented principle is verified by experiment. Digital microinjection has been realized, particularly under conditions that neither micro moving parts nor embedded micro electric circuits are necessary, hence greatly simplifying the structure and reducing the cost. The microfluidic system can work normally over a rather wide range, even though where very large resistance to flow exists. The amount of injected fluid material may reach an ultra high resolution of the order of femtoliters. The kinds of the fluid materials that can be injected include conventional liquids as well as solid powders, pastes, and other substances of similar characteristics. Furthermore, the digital femtoliter microinjector can be expected for making nano particles.

Paper Details

Date Published: 23 December 2003
PDF: 10 pages
Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); doi: 10.1117/12.524993
Show Author Affiliations
Weiyi Zhang, Nanjing Univ. of Science and Technology (China)
Liya Hou, Nanjing Univ. of Science and Technology (China)
Lili Mu, Anhui Univ. of Science and Technology (China)
Li Zhu, Nanjing Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 5345:
Microfluidics, BioMEMS, and Medical Microsystems II
Peter Woias; Ian Papautsky, Editor(s)

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