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Proceedings Paper

Toward a disposable real-time DNA biosensing platform
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Paper Abstract

With the goal of a portable diagnostic system in mind, we have designed a disposable platform for DNA detection. Surface micromachining using the SwIFT process at Sandia National Laboratories was used to make the new device, combining a waveguide, grating optics, heating structures, on-chip pumping, and microfluidics in a disposable package. PDMS microfluidic channels are integrated with the surface micromachined device to enable higher flow rates and added fluid complexity. Work on DNA hybridization under flow is presented, as applies to the function of the sensor. A description of the platform covering heating of the waveguide surface, laser coupling into the waveguide using grating optics, attachment chemistry for the sensor surface, and sealing of the PDMS microfluidic system to the device is given.

Paper Details

Date Published: 23 December 2003
PDF: 7 pages
Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); doi: 10.1117/12.524629
Show Author Affiliations
Layne D. Williams, Univ. of Utah (United States)
Justin Bishop, Univ. of Utah (United States)
Steve Blair, Univ. of Utah (United States)
David W. Peters, Sandia National Labs. (United States)
Murat Okandan, Sandia National Labs. (United States)

Published in SPIE Proceedings Vol. 5345:
Microfluidics, BioMEMS, and Medical Microsystems II
Peter Woias; Ian Papautsky, Editor(s)

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