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Proceedings Paper

In vitro investigation on cytotoxic activity of TS4PP [5,10,15,20-tetra (4-sulfophenyl) porphyrin]
Author(s): R. Alexandrova; Rodica-Mariana Ion; Elena V. Stoykova; Stanislav Shurulinkov
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Paper Abstract

Photodynamic therapy (PDT) is a treatment modality that uses a drug and light to kill tumor cells. A large number of photosensitizing agents have been tested in PDT exeperiments. The aim of the present study was to evaluate an effect of 5, 10, 15, 20-tetra (4-sulfophenyl) porphyrin (TS4PP) on viability of tumor (LSR-SF-SR, LSCC-SF-Mc29) and non-tumor (EBTr, L929) cell lines in vitro. The experiments were performed using neutral red uptake cytotoxicity test. Different concentrations -- 10, 100, 250 and 500 μg/ml, were tested. Light at 514 nm was applied using Ar-ion laser. The light doses delivered varied from 0.2 up to 2 J/cm2. The effect of the compound without irradiation was also examined.

Paper Details

Date Published: 4 November 2003
PDF: 5 pages
Proc. SPIE 5226, 12th International School on Quantum Electronics: Laser Physics and Applications, (4 November 2003); doi: 10.1117/12.519586
Show Author Affiliations
R. Alexandrova, Institute of Experimental Pathology and Parasitology (Bulgaria)
Rodica-Mariana Ion, Institute for Chemical Research (Romania)
Elena V. Stoykova, Central Lab. for Optical Storage and Processing of Information (Bulgaria)
Stanislav Shurulinkov, Central Lab. for Optical Storage and Processing of Information (Bulgaria)


Published in SPIE Proceedings Vol. 5226:
12th International School on Quantum Electronics: Laser Physics and Applications
Peter A. Atanasov; Alexander A. Serafetinides; Ivan N. Kolev, Editor(s)

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