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Proceedings Paper

Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy
Author(s): Vladislav Toronov; Andrew Webb; Scott Walker; Rajarsi Gupta; Jee Hyun Choi; Enrico Gratton; Dennis M. Hueber
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Paper Abstract

In order to study the behavior of cerebral physiological parameters and to further the understanding of the fMRI blood-oxygen-level-dependent (BOLD) effect, we have recorded simultaneously multi-source frequency-domain near-infrared and BOLD fMRI signals during motor functional activation in humans. From the near-infrared data we obtained information on the changes in cerebral blood volume and oxygenation. In order to relate our observations to changes in cerebral blood flow we employed the “balloon” model of cerebral perfusion. Our data showed that the deoxyhemoglobin concentration is the major factor determining the time course of the BOLD signal.

Paper Details

Date Published: 13 October 2003
PDF: 5 pages
Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); doi: 10.1117/12.518770
Show Author Affiliations
Vladislav Toronov, Univ. of Illinois, Urbana-Champaign (United States)
Andrew Webb, Univ. of Illinois, Urbana-Champaign (United States)
Scott Walker, Univ. of Illinois, Urbana-Champaign (United States)
Rajarsi Gupta, Univ. of Illinois, Urbana-Champaign (United States)
Jee Hyun Choi, Univ. of Illinois, Urbana-Champaign (United States)
Enrico Gratton, Univ. of Illinois, Urbana-Champaign (United States)
Dennis M. Hueber, ISS, Inc. (United States)


Published in SPIE Proceedings Vol. 5068:
Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV
Valery V. Tuchin, Editor(s)

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