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Proceedings Paper

Near-infrared spectroscopy and polysomnography during all-night sleep in human subjects
Author(s): Sergio Fantini; Payal Aggarwal; Kathleen Chen; Maria Angela Franceschini; Bruce L. Ehrenberg
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Paper Abstract

We have performed cerebral near-infrared spectroscopy (NIRS) and polysomnography (electro-encephalography, electro-oculography, electro-myography, pulse oximetry, and respiratory monitoring) during all-night sleep in five human subjects. Polysomnography data were used for sleep staging, while NIRS data were used to measure the concentration and the oxygen saturation of hemoglobin in the frontal brain region. Immediately after sleep onset we observed a decrease in the cerebral concentration of oxy-hemoglobin ([HbO2]) and an increase in the concentration of deoxy-hemoglobin ([Hb]), consistent with a decrease in the cerebral blood flow velocity or an increase in cerebral metabolic rate of oxygen. An opposite trend (increase in [HbO2] and decrease in [Hb]) was usually observed after transition to deep sleep (stages III and IV). During rapid eye movement (REM) sleep, we observed an increase in [HbO2] and decrease in [Hb], consistent with an increase in the cerebral blood flow that overcompensates the increase in the metabolic rate of oxygen associated with REM sleep.

Paper Details

Date Published: 13 October 2003
PDF: 8 pages
Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); doi: 10.1117/12.518756
Show Author Affiliations
Sergio Fantini, Tufts Univ. (United States)
Payal Aggarwal, Tufts Univ. (United States)
Kathleen Chen, Tufts Univ. (United States)
Maria Angela Franceschini, Tufts Univ. (United States)
Harvard Medical School (United States)
Bruce L. Ehrenberg, Tufts Univ. School of Medicine (United States)
Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 5068:
Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV
Valery V. Tuchin, Editor(s)

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