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Proceedings Paper

Improvement of photodynamic activity of aluminium sulphophthalocyanine due to biotinylation
Author(s): Irina G. Meerovich; Victoria V. Jerdeva; Valentina M. Derkacheva; Gennadii A. Meerovich; Eugeny A. Lukyanets; Eugenia A. Kogan; Alexander P. Savitsky
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Paper Abstract

The photodynamic activity of dibiotinylated aluminium sulphophthalocyanine in vitro and in vivo were studied. It was obtained that in vitro dibiotinylated aluminium sulphophthalocyanine provides the effective damage of small cell lung carcinoma OAT-75. In vivo dibiotinylated aluminium sulphophthalocyanine causes destruction of tumor (Erlich carcinoma), results in total necrosis of tumor tissue and expresses vascular damage (trombosis and destruction of vascular walls) even in concentration 0.25 mg/kg of a body weight.

Paper Details

Date Published: 22 September 2003
PDF: 7 pages
Proc. SPIE 5149, Laser Applications in Medicine, Biology, and Environmental Science, (22 September 2003); doi: 10.1117/12.518711
Show Author Affiliations
Irina G. Meerovich, A.N. Bakh Institute of Biochemistry (Russia)
Victoria V. Jerdeva, A.N. Bakh Institute of Biochemistry (Russia)
Valentina M. Derkacheva, Organic Intermediates and Dyes Institute (Russia)
Gennadii A. Meerovich, A.M. Prokhorov General Physics Institute (Russia)
Eugeny A. Lukyanets, Organic Intermediates and Dyes Institute (Russia)
Eugenia A. Kogan, I.M. Sechenov Moscow Medical Academy (Russia)
Alexander P. Savitsky, A.N. Bakh Institute of Biochemistry (Russia)


Published in SPIE Proceedings Vol. 5149:
Laser Applications in Medicine, Biology, and Environmental Science
Gerhard Mueller; Valery V. Tuchin; Gennadii G. Matvienko; Christian Werner; Vladislav Ya. Panchenko, Editor(s)

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